Gene Expression Literature Summary

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Wt1  WT1 transcription factor   (Synonyms: D630046I19Rik, Wilms tumor 1 homolog, Wt-1)
Results	Reference
1	J:263978 Ariza L, Canete A, Rojas A, Munoz-Chapuli R, Carmona R, Role of the Wilms' tumor suppressor gene Wt1 in pancreatic development. Dev Dyn. 2018 Apr 30;
1	J:170930 Asahina K, Zhou B, Pu WT, Tsukamoto H, Septum transversum-derived mesothelium gives rise to hepatic stellate cells and perivascular mesenchymal cells in developing mouse liver. Hepatology. 2011 Mar;53(3):983-95
1	J:183991 Baek ST, Tallquist MD, Nf1 limits epicardial derivative expansion by regulating epithelial to mesenchymal transition and proliferation. Development. 2012 Jun;139(11):2040-9
1	J:311885 Bandiera R, Vidal VP, Motamedi FJ, Clarkson M, Sahut-Barnola I, von Gise A, Pu WT, Hohenstein P, Martinez A, Schedl A, WT1 maintains adrenal-gonadal primordium identity and marks a population of AGP-like progenitors within the adrenal gland. Dev Cell. 2013 Oct 14;27(1):5-18
1*	J:162870 Bax NA, Bleyl SB, Gallini R, Wisse LJ, Hunter J, Van Oorschot AA, Mahtab EA, Lie-Venema H, Goumans MJ, Betsholtz C, Gittenberger-de Groot AC, Cardiac malformations in Pdgfralpha mutant embryos are associated with increased expression of WT1 and Nkx2.5 in the second heart field. Dev Dyn. 2010 Aug;239(8):2307-17
1	J:68750 Cacalano G, Farinas I, Wang LC, Hagler K, Forgie A, Moore M, Armanini M, Phillips H, Ryan AM, Reichardt LF, Hynes M, Davies A, Rosenthal A, GFRalpha1 is an essential receptor component for GDNF in the developing nervous system and kidney. Neuron. 1998 Jul;21(1):53-62
1	J:137459 Cai CL, Martin JC, Sun Y, Cui L, Wang L, Ouyang K, Yang L, Bu L, Liang X, Zhang X, Stallcup WB, Denton CP, McCulloch A, Chen J, Evans SM, A myocardial lineage derives from Tbx18 epicardial cells. Nature. 2008 Jul 3;454(7200):104-8
1	J:226657 Callier P, Calvel P, Matevossian A, Makrythanasis P, Bernard P, Kurosaka H, Vannier A, Thauvin-Robinet C, Borel C, Mazaud-Guittot S, Rolland A, Desdoits-Lethimonier C, Guipponi M, Zimmermann C, Stevant I, Kuhne F, Conne B, Santoni F, Lambert S, Huet F, Mugneret F, Jaruzelska J, Faivre L, Wilhelm D, Jegou B, Trainor PA, Resh MD, Antonarakis SE, Nef S, Loss of function mutation in the palmitoyl-transferase HHAT leads to syndromic 46,XY disorder of sex development by impeding Hedgehog protein palmitoylation and signaling. PLoS Genet. 2014 May;10(5):e1004340
1	J:205073 Cano E, Carmona R, Munoz-Chapuli R, Wt1-expressing progenitors contribute to multiple tissues in the developing lung. Am J Physiol Lung Cell Mol Physiol. 2013 Aug 15;305(4):L322-32
1*	J:229936 Cano E, Carmona R, Ruiz-Villalba A, Rojas A, Chau YY, Wagner KD, Wagner N, Hastie ND, Munoz-Chapuli R, Perez-Pomares JM, Extracardiac septum transversum/proepicardial endothelial cells pattern embryonic coronary arterio-venous connections. Proc Natl Acad Sci U S A. 2016 Jan 19;113(3):656-61
1	J:304944 Carmona R, Barrena S, Lopez Gambero AJ, Rojas A, Munoz-Chapuli R, Epicardial cell lineages and the origin of the coronary endothelium. FASEB J. 2020 Apr;34(4):5223-5239
1	J:134687 Chang H, Gao F, Guillou F, Taketo MM, Huff V, Behringer RR, Wt1 negatively regulates {beta}-catenin signaling during testis development. Development. 2008 May;135(10):1875-85
1	J:225062 Chen SR, Zheng QS, Zhang Y, Gao F, Liu YX, Disruption of genital ridge development causes aberrant primordial germ cell proliferation but does not affect their directional migration. BMC Biol. 2013;11:22
1	J:208428 Chu JY, Sims-Lucas S, Bushnell DS, Bodnar AJ, Kreidberg JA, Ho J, Dicer function is required in the metanephric mesenchyme for early kidney development. Am J Physiol Renal Physiol. 2014 Apr;306(7):F764-72
1	J:301645 Cleal L, McHaffie SL, Lee M, Hastie N, Martinez-Estrada OM, Chau YY, Resolving the heterogeneity of diaphragmatic mesenchyme: a novel mouse model of congenital diaphragmatic hernia. Dis Model Mech. 2021 Jan 26;14(1)
1	J:197449 Coles GL, Ackerman KG, Kif7 is required for the patterning and differentiation of the diaphragm in a model of syndromic congenital diaphragmatic hernia. Proc Natl Acad Sci U S A. 2013 May 21;110(21):E1898-905
1	J:313609 Diaz Del Moral S, Barrena S, Hernandez-Torres F, Aranega A, Villaescusa JM, Gomez Doblas JJ, Franco D, Jimenez-Navarro M, Munoz-Chapuli R, Carmona R, Deletion of the Wilms' Tumor Suppressor Gene in the Cardiac Troponin-T Lineage Reveals Novel Functions of WT1 in Heart Development. Front Cell Dev Biol. 2021;9:683861
1	J:256264 Diman NY, Brooks G, Kruithof BP, Elemento O, Seidman JG, Seidman CE, Basson CT, Hatcher CJ, Tbx5 is required for avian and Mammalian epicardial formation and coronary vasculogenesis. Circ Res. 2014 Oct 24;115(10):834-44
1	J:204973 Dixit R, Ai X, Fine A, Derivation of lung mesenchymal lineages from the fetal mesothelium requires hedgehog signaling for mesothelial cell entry. Development. 2013 Nov;140(21):4398-406
1	J:225761 Duim SN, Kurakula K, Goumans MJ, Kruithof BP, Cardiac endothelial cells express Wilms' tumor-1: Wt1 expression in the developing, adult and infarcted heart. J Mol Cell Cardiol. 2015 Apr;81:127-35
1	J:157308 Gai Z, Zhou G, Itoh S, Morimoto Y, Tanishima H, Hatamura I, Uetani K, Ito M, Muragaki Y, Trps1 functions downstream of Bmp7 in kidney development. J Am Soc Nephrol. 2009 Nov;20(11):2403-11
1	J:213513 Gao Y, Toska E, Denmon D, Roberts SG, Medler KF, WT1 regulates the development of the posterior taste field. Development. 2014 Jun;141(11):2271-8
1*	J:65872 Georgas K, Bowles J, Yamada T, Koopman P, Little MH, Characterisation of crim1 expression in the developing mouse urogenital tract reveals a sexually dimorphic gonadal expression pattern. Dev Dyn. 2000 Dec;219(4):582-7
1	J:153202 Gerber SD, Steinberg F, Beyeler M, Villiger PM, Trueb B, The murine Fgfrl1 receptor is essential for the development of the metanephric kidney. Dev Biol. 2009 Nov 1;335(1):106-19
1	J:342844 Harvey AB, Wolters RA, Deepe RN, Tarolli HG, Drummond JR, Trouten A, Zandi A, Barth JL, Mukherjee R, Romeo MJ, Vaena SG, Tao G, Muise-Helmericks R, Ramos PS, Norris RA, Wessels A, Epicardial deletion of Sox9 leads to myxomatous valve degeneration and identifies Cd109 as a novel gene associated with valve development. J Mol Cell Cardiol. 2023 Nov 5;186:16-30
1	J:338840 Hertig V, Villeneuve L, Calderone A, Nestin identifies a subpopulation of rat ventricular fibroblasts and participates in cell migration. Am J Physiol Cell Physiol. 2023 Aug 1;325(2):C496-C508
1	J:160733 Ivaniutsin U, Chen Y, Mason JO, Price DJ, Pratt T, Adenomatous polyposis coli is required for early events in the normal growth and differentiation of the developing cerebral cortex. Neural Dev. 2009;4:3
1	J:334751 Jiang H, Bai L, Song S, Yin Q, Shi A, Zhou B, Lian H, Chen H, Xu CR, Wang Y, Nie Y, Hu S, EZH2 controls epicardial cell migration during heart development. Life Sci Alliance. 2023 Jun;6(6)
1	J:314126 Jiang H, Song S, Li J, Yin Q, Hu S, Nie Y, Establishment and characterization of an immortalized epicardial cell line. J Cell Mol Med. 2021 Apr 6;
1	J:177490 Jongbloed MR, Vicente-Steijn R, Douglas YL, Wisse LJ, Mori K, Yokota Y, Bartelings MM, Schalij MJ, Mahtab EA, Poelmann RE, Gittenberger-De Groot AC, Expression of Id2 in the second heart field and cardiac defects in Id2 knock-out mice. Dev Dyn. 2011 Nov;240(11):2561-77
1	J:284905 Kabayiza KU, Masgutova G, Harris A, Rucchin V, Jacob B, Clotman F, The Onecut Transcription Factors Regulate Differentiation and Distribution of Dorsal Interneurons during Spinal Cord Development. Front Mol Neurosci. 2017;10:157
1	J:253729 Kelder TP, Duim SN, Vicente-Steijn R, Vegh AM, Kruithof BP, Smits AM, van Bavel TC, Bax NA, Schalij MJ, Gittenberger-de Groot AC, DeRuiter MC, Goumans MJ, Jongbloed MR, The epicardium as modulator of the cardiac autonomic response during early development. J Mol Cell Cardiol. 2015 Dec;89(Pt B):251-9
1	J:166272 Kirschner KM, Sciesielski LK, Scholz H, Wilms' tumour protein Wt1 stimulates transcription of the gene encoding vascular endothelial cadherin. Pflugers Arch. 2010 Nov;460(6):1051-61
1	J:206877 Kolander KD, Holtz ML, Cossette SM, Duncan SA, Misra RP, Epicardial GATA factors regulate early coronary vascular plexus formation. Dev Biol. 2014 Feb 1;386(1):204-15
1*	J:170390 Lindstrom NO, Neves C, McIntosh R, Miedzybrodzka Z, Vargesson N, Martin Collinson J, Tissue specific characterisation of Lim-kinase 1 expression during mouse embryogenesis. Gene Expr Patterns. 2011 Mar-Apr;11(3-4):221-32
1	J:237537 Liu C, Rodriguez K, Yao HH, Mapping lineage progression of somatic progenitor cells in the mouse fetal testis. Development. 2016 Oct 15;143(20):3700-3710
1	J:222842 Liu Y, Lu X, Xiang FL, Poelmann RE, Gittenberger-de Groot AC, Robbins J, Feng Q, Nitric oxide synthase-3 deficiency results in hypoplastic coronary arteries and postnatal myocardial infarction. Eur Heart J. 2014 Apr;35(14):920-31
1	J:340446 Lotto J, Cullum R, Drissler S, Arostegui M, Garside VC, Fuglerud BM, Clement-Ranney M, Thakur A, Underhill TM, Hoodless PA, Cell diversity and plasticity during atrioventricular heart valve EMTs. Nat Commun. 2023 Sep 9;14(1):5567
1	J:192186 Maatouk DM, Mork L, Hinson A, Kobayashi A, McMahon AP, Capel B, Germ cells are not required to establish the female pathway in mouse fetal gonads. PLoS One. 2012;7(10):e47238
1	J:346139 Mah SYY, Vanyai HK, Li-Wai-Suen CSN, Garnham AL, Wynn J, Bergamasco MI, Malelang S, Wilcox S, Biben C, Smyth GK, Thomas T, Voss AK, ING4 and ING5 are essential for histone H3 lysine 14 acetylation and epicardial cell lineage development. Development. 2024 Mar 1;151(5):dev202617
1*	J:132132 Mahtab EA, Wijffels MC, Van Den Akker NM, Hahurij ND, Lie-Venema H, Wisse LJ, Deruiter MC, Uhrin P, Zaujec J, Binder BR, Schalij MJ, Poelmann RE, Gittenberger-De Groot AC, Cardiac malformations and myocardial abnormalities in podoplanin knockout mouse embryos: Correlation with abnormal epicardial development. Dev Dyn. 2008 Mar;237(3):847-57
1*	J:283401 Masgutova G, Harris A, Jacob B, Corcoran LM, Clotman F, Pou2f2 Regulates the Distribution of Dorsal Interneurons in the Mouse Developing Spinal Cord. Front Mol Neurosci. 2019;12:263
1	J:314041 Moazzen H, Venger K, Kant S, Leube RE, Krusche CA, Desmoglein 2 regulates cardiogenesis by restricting hematopoiesis in the developing murine heart. Sci Rep. 2021 Nov 4;11(1):21687
1	J:309384 Neirijnck Y, Reginensi A, Renkema KY, Massa F, Kozlov VM, Dhib H, Bongers EMHF, Feitz WF, van Eerde AM, Lefebvre V, Knoers NVAM, Tabatabaei M, Schulz H, McNeill H, Schaefer F, Wegner M, Sock E, Schedl A, Sox11 gene disruption causes congenital anomalies of the kidney and urinary tract (CAKUT). Kidney Int. 2018 May;93(5):1142-1153
1	J:171035 Norden J, Grieskamp T, Lausch E, van Wijk B, van den Hoff MJ, Englert C, Petry M, Mommersteeg MT, Christoffels VM, Niederreither K, Kispert A, Wt1 and retinoic acid signaling in the subcoelomic mesenchyme control the development of the pleuropericardial membranes and the sinus horns. Circ Res. 2010 Apr 16;106(7):1212-20
1	J:227024 Paris ND, Coles GL, Ackerman KG, Wt1 and beta-catenin cooperatively regulate diaphragm development in the mouse. Dev Biol. 2015 Nov 1;407(1):40-56
1	J:23778 Ryan G, Steele-Perkins V, Morris JF, Rauscher FJ 3rd, Dressler GR, Repression of Pax-2 by WT1 during normal kidney development. Development. 1995 Mar;121(3):867-75
1	J:302572 Schnerwitzki D, Hayn C, Perner B, Englert C, Wt1 Positive dB4 Neurons in the Hindbrain Are Crucial for Respiration. Front Neurosci. 2020;14:529487
1	J:287023 Schnerwitzki D, Perry S, Ivanova A, Caixeta FV, Cramer P, Gunther S, Weber K, Tafreshiha A, Becker L, Vargas Panesso IL, Klopstock T, Hrabe de Angelis M, Schmidt M, Kullander K, Englert C, Neuron-specific inactivation of Wt1 alters locomotion in mice and changes interneuron composition in the spinal cord. Life Sci Alliance. 2018 Aug;1(4):e201800106
1	J:115344 Self M, Lagutin OV, Bowling B, Hendrix J, Cai Y, Dressler GR, Oliver G, Six2 is required for suppression of nephrogenesis and progenitor renewal in the developing kidney. EMBO J. 2006 Nov 1;25(21):5214-28
1	J:85949 Shikama N, Lutz W, Kretzschmar R, Sauter N, Roth JF, Marino S, Wittwer J, Scheidweiler A, Eckner R, Essential function of p300 acetyltransferase activity in heart, lung and small intestine formation. EMBO J. 2003 Oct 1;22(19):5175-85
1	J:235463 Singh A, Ramesh S, Cibi DM, Yun LS, Li J, Li L, Manderfield LJ, Olson EN, Epstein JA, Singh MK, Hippo Signaling Mediators Yap and Taz Are Required in the Epicardium for Coronary Vasculature Development. Cell Rep. 2016 May 17;15(7):1384-93
1	J:223201 Song R, Preston G, Ichihara A, Yosypiv IV, Deletion of the prorenin receptor from the ureteric bud causes renal hypodysplasia. PLoS One. 2013;8(5):e63835
1*	J:341715 Sui Y, Kou S, Ge K, Cao J, Liu C, Zhang H, Expression analysis of plvap in mouse heart development, homeostasis and injury. Gene Expr Patterns. 2023 Sep 28;50:119343
1	J:62879 Tevosian SG, Deconinck AE, Tanaka M, Schinke M, Litovsky SH, Izumo S, Fujiwara Y, Orkin SH, FOG-2, a cofactor for GATA transcription factors, is essential for heart morphogenesis and development of coronary vessels from epicardium. Cell. 2000 Jun 23;101(7):729-39
1	J:243174 Vicente-Steijn R, Scherptong RW, Kruithof BP, Duim SN, Goumans MJ, Wisse LJ, Zhou B, Pu WT, Poelmann RE, Schalij MJ, Tallquist MD, Gittenberger-de Groot AC, Jongbloed MR, Regional differences in WT-1 and Tcf21 expression during ventricular development: implications for myocardial compaction. PLoS One. 2015;10(9):e0136025
1	J:187162 Wachi T, Yoshida N, Funae Y, Ueno M, Germino GG, Hirotsune S, Deguchi N, Progesterone induced mesenchymal differentiation and rescued cystic dilation of renal tubules of Pkd1(-/-) mice. Biochem Biophys Res Commun. 2012 Aug 24;425(2):212-8
1	J:171496 Wagner N, Morrison H, Pagnotta S, Michiels JF, Schwab Y, Tryggvason K, Schedl A, Wagner KD, The podocyte protein nephrin is required for cardiac vessel formation. Hum Mol Genet. 2011 Jun 1;20(11):2182-94
1	J:111672 Wagner N, Wagner KD, Scholz H, Kirschner KM, Schedl A, Intermediate filament protein nestin is expressed in developing kidney and heart and might be regulated by the Wilms' tumor suppressor Wt1. Am J Physiol Regul Integr Comp Physiol. 2006 Sep;291(3):R779-87
1	J:102417 Wagner N, Wagner KD, Theres H, Englert C, Schedl A, Scholz H, Coronary vessel development requires activation of the TrkB neurotrophin receptor by the Wilms' tumor transcription factor Wt1. Genes Dev. 2005 Nov 1;19(21):2631-42
1	J:277545 Wang Y, Li Q, Liu C, Han F, Chen M, Zhang L, Cui X, Qin Y, Bao S, Gao F, Protein arginine methyltransferase 5 (Prmt5) is required for germ cell survival during mouse embryonic development. Biol Reprod. 2015 Apr;92(4):104
1	J:255737 Wei K, Diaz-Trelles R, Liu Q, Diez-Cunado M, Scimia MC, Cai W, Sawada J, Komatsu M, Boyle JJ, Zhou B, Ruiz-Lozano P, Mercola M, Developmental origin of age-related coronary artery disease. Cardiovasc Res. 2015 Jul 15;107(2):287-94
1	J:309601 Wei K, Serpooshan V, Hurtado C, Diez-Cunado M, Zhao M, Maruyama S, Zhu W, Fajardo G, Noseda M, Nakamura K, Tian X, Liu Q, Wang A, Matsuura Y, Bushway P, Cai W, Savchenko A, Mahmoudi M, Schneider MD, van den Hoff MJ, Butte MJ, Yang PC, Walsh K, Zhou B, Bernstein D, Mercola M, Ruiz-Lozano P, Epicardial FSTL1 reconstitution regenerates the adult mammalian heart. Nature. 2015 Sep 24;525(7570):479-85
1	J:300975 Weiss AC, Rivera-Reyes R, Englert C, Kispert A, Expansion of the renal capsular stroma, ureteric bud branching defects and cryptorchidism in mice with Wilms tumor 1 gene deletion in the stromal compartment of the developing kidney. J Pathol. 2020 Nov;252(3):290-303
1*	J:338819 Wulf S, Mizko L, Herrmann KH, Sanchez-Carbonell M, Urbach A, Lemke C, Berndt A, Loeffler I, Wolf G, Targeted Disruption of the MORG1 Gene in Mice Causes Embryonic Resorption in Early Phase of Development. Biomolecules. 2023 Jun 24;13(7)
1*	J:320689 Xu J, Li J, Ramakrishnan A, Yan H, Shen L, Xu PX, Six1 and Six2 of the Sine Oculis Homeobox Subfamily are Not Functionally Interchangeable in Mouse Nephron Formation. Front Cell Dev Biol. 2022;10:815249
1	J:250210 Xu J, Wong EY, Cheng C, Li J, Sharkar MT, Xu CY, Chen B, Sun J, Jing D, Xu PX, Eya1 interacts with Six2 and Myc to regulate expansion of the nephron progenitor pool during nephrogenesis. Dev Cell. 2014 Nov 24;31(4):434-47
1	J:177189 Zeng B, Ren XF, Cao F, Zhou XY, Zhang J, Developmental patterns and characteristics of epicardial cell markers Tbx18 and Wt1 in murine embryonic heart. J Biomed Sci. 2011;18:67
1	J:320908 Zheng F, Chen Z, Tang QL, Wang XY, Chong DY, Zhang TY, Gu YY, Hu ZB, Li CJ, Cholesterol metabolic enzyme Ggpps regulates epicardium development and ventricular wall architecture integrity in mice. J Mol Cell Biol. 2021 Sep 11;13(6):445-454